Mona Zaki was born to parents Ali Mohamed Zaki and Tahani, on November 18, 1976. By the time she was 13, she had already been to England, Kuwait and the United States. When she was 16, luck changed the course of her life. Upon seeing Mohamed Sobhi's advertisement for new faces, she applied merely in hope of getting a chance to meet the famous Egyptian actor and director. However, she got much more than that; namely her first acting role in his play Bel Araby El Faseeh.

When it was finally time for Mona to go to college, she enrolled in the Faculty of Mass Communications at Cairo University. During that time, she was introduced to director Ismail Abdel Hafez who chose her to play a part in El A'elah, a Ramadan series that marked her TV debut. Acting became more than just a hobby to Mona after that; she later acted in a number of popular TV series: Khalti Safiya wel Deir, Nisf Rabi' El Akhar, Ahalina, Ded El Tayyar and El Daw' El Sharid.

The promising star's distinguished TV roles opened the doors of the big silver screen for her. Mona invaded the cinema with El Katl ElLaziz, with Mervat Amin, then went on to play lead roles in Idhak El Soura Titla' Hilwa - a performance for which she received an award - Sa'idi fil Gam'a Al-Amrikiya, Omar 2000, El Hobb El Awal, and Leih Khallitni Ahibbak - all of which were box office hits.
But Mona really outdid herself and all her previous roles, when she played the role of Gihan El Sadat in the masterpiece Ayam El Sadat. The young actress was given an award, along with the rest of the cast of the movie, by President Hosni Mubarak, which served as an encouragement for her.

Success remained close to the talented star and her dedication was well rewarded with the huge popularity of her next movies Africano and Mafia. But Mona didn't stop there. She went on from one hit to another, presenting Sahar El Layali, Men Nazret Ein and finally Khalti Faransa - now playing in theatres. Each film came with a different role but with the same triumph.
Despite her huge success in the cinema, Mona's heart remained with the theater and during her career presented several plays, among which were Le'b Eyal, Ya Messafer Wahdak, Afrouto and Keda Ok.

As for her personal life, Mona Zaki is living a quiet and happy family life. She married the talented actor, Ahmed Helmy, and is now the mother of a young girl; Lily. Mona's favorite actor and actress are Souad Hosny and Ahmed Zaki