The Toxicology of Fishes

By

Richard T. Di Giulio & David E. Hinton

Contents

Unit 1: General Principles

1. Bioavailability of Chemical Contaminants in Aquatic Systems

2.  Toxicokinetics in Fishes

3.  Biotransformation in Fishes

4.  Receptor-Mediated Mechanisms of Toxicity

5.  Reactive Oxygen Species and Oxidative Stress

Unit 2: Key Target Systems and Organismal Effects

1.  Liver Toxicity

2.  The Osmoregulatory System

3.  Toxic Responses of the Fish Nervous System

4.  The Endocrine System

5.  The Immune System of Fish: A Target Organ of Toxicity

6.  Chemical Carcinogenesis in Fishes

7.  Toxicity Resistance

Unit 3: Methodologies and Applications

1.  Exposure Assessment and Modeling in the Aquatic Environment

2.  Fish Toxicity

3.  Biomarkers

4.  Aquatic Ecosystems for Ecotoxicological Research: Considerations in Design Analysis for Fish

5.  Ecological Risk Assessment

Unit 4: Case Studies

1. Mining Impacts on Fish in the Clark Fork River, Montana: A Field Ecotoxicology Case Study

2.  Toxicology of Synthetic Pyrethroid Insecticdes in Fish: A Case Study

3.  Reproductive Impairment of Great Lakes- Lake Trout by Dioxin-Like Chemicals

4.  The Effects of Polycyclic Aromatic Hydrocarbons in Fish from Puget Sound, Washington

5.  Effects of the Exxon Valdez oil Spill on Pacific Herring in Prince William Sound, Alaska

6.  Case Study: Pulp and Paper Mill Impacts

7. Estrogenic Effects of Treated Sewage Effluent on Fish: Steroids and Surfactants in English Rivers

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Prep. / Ayman Ashry

Rev. / Asmaa Ahmed

Manage. / Huda Hosny