Cercospora leaf spot (CLS), early leaf spot (caused by Cercospora arachidicola) and late leaf spot (caused by Cercosporidium personatum) are the most important foliar diseases affecting peanut (Arachis hypogaea L.) throughout the world. Although, fungicide applications considered one of the important management strategies for controlling of CLS however, it causes hazards to human and animal health and increase environmental pollution, which makes the urgent need to find fungicides alternatives. In try to take this approach, the effectiveness of biotic inducers (Pseudomonas fluorescens and Bacillus subtilis) and abiotic inducers (chitosan at 1, 2 & 3 mM and bion at 2,4 & 8 mM), were tested in field trials on incidence of CLS compared to commercial fungicide as a check treatment. All tested inducers significantly reduced diseases severity of CLS compared to non-treated control in the two successive seasons 2018 and 2019. Generally, chitosan at 3mM and followed by chitosan at 2 mM and P. fluorescens gave the highest effect on reducing of CLS. While, bion at 2 mM gave the highest value of disease severity compared with control treatment in the two successive seasons. Increasing the concentration of chemical inducers (Abiotic treatments) caused increase in their reducing efficiency of diseases severity. This study indicated that, there is a correlation between induced resistance and some biochemical changes in peanut leaf tissues. Among these biochemical changes, the increase of phenol contents (free, conjugate & total phenols) and oxidative enzyme activity (peroxidase, polyphenoloxidase and catalase) as well as total free amino acids and percentage of crude protein. The obtained data clearly showed the ability of some inducers treatments to achieve efficacy close to the efficiency of commercial fungicide in reducing CLS in peanuts, which may encourage the use of these inducers as an alternative to fungicides.