Dr Ahmed Ragab Hamed

Name: Ahmed Ragab Mohamed Hamed

Address: Chemitry of Medicinal Plants Department (formerly Phytochemitry), Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, 12622, Egypt

Email: [email protected]

Tel No: 00201090221769.

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Education: 

-PhD in Biomedical Sciences from the University of Nottingham, United Kingdom (2005-2009).

- M.Sc in Biochemistry, faculty of Science, Ain Shams University, Cairo, Egypt (1999- 2002).

B.Sc in Biochemistry, faculty of Science, Ain Shams University, Cairo, Egypt (1991-1995).

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Positions

-August 2016-present:Associate Professor of Therapeutic Biochemistry, Department of Chemsitry of Medicinal Plants (formerly Phytochemistry), Pharmaceutical and Drug Industries Research Division, National Research Centre, Egypt.

-Feb 2010-July, 2016: lecturer (Researcher) at Department of Phytochemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Egypt.

-Feb 2005-Dec 2009: Full Time PhD Student, Centre for Biochemistry and Cell Biology, School of Biomedical Sciences, the University of Nottingham, UK.

-Aug 2002-Jan 2005: Assistant Researcher at Department of Phytochemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Egypt.

-March 2002-Aug 2002: Department of Phytochemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Egypt.

-1998-2002:Research Biochemist at Department of Phytochemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Egypt.

Participation in Scientific Research Projects:

1-National Research Centre (NRC)-funded Project: ‘Sinai Wild Plants: A Forthcoming Nominee as a Source for Cancer MultiDrug Resistance Chemosensitizers and Cancer Preventive agents’ as Principal Investigator (running project)

2- NRC-funded Project: ‘Egyptian plants of family Arecaceae as cancer chemopreventive and antiproliferative agent’ as Research Team member (running project)

3-STDF-funded Project: ''Therapeutic model for RNA Interference and miRNA 

Mimicking to Target the Multidrug Resistance in Cancer Cell'' as Co-PI (a finished project).

4-STDF-funded Project: ‘’Metabolomics approaches to evaluate the effectiveness and safety of new herbal medications and chemical entities’’ as Research Team member (a finished project).

5-NRC-funded Project: ‘’Metabolomics: The road for therapeutic drug discovery from natural sources and synthetic compounds as well as early diagnosis of liver cancer’’ as Research Team member (a finished Project).

Student Supervision

Currently supervising 2 master students and 4 PhD students in Science and Pharmacy degrees.

Awards

1-Award of PhD scholarship from Egypt to study in the University of Nottingham, UK, 2005-2009.

2-Award of 2 postgraduate grants from the International Society for Medicinal Plant Research (GA society), Finland and Austria, 2006 and 2007, respectively.

3-Award of Research Excellence, presented by the Egyptian Student Union, University 

of Nottingham, 2008.

4-Award of  University of Nottingham travel prize for GA conference, 2006.

Scientific Missions

-PhD Scholarship to the University of Nottingham (2005-2009)

-GA Conference 2014 in Portugal (Aug-sep 2014).

-Two month scientific mission to the Cancer Research Division, University of Dundee, Scotland ( Aug-Sep 2015)

Scientific Memberships:

-International Society of medicinal Plant research GA, Germany. 

-Egyptian Society of Biochemistry and Molecular Biology.

-Arab Society of Medicinal Plant Research.

-Arab society for Medical Research

-Egyptian Society of Chemistry

Main Research /Technology Topics 

1-In vitro investigation of protein expression inductions in mammalian cell lines with 

variety of phytochemicals.

2-Mechanism-based investigation of cancer chemopreventive activities of natural products(Induction of cytoprotective proteins).

3-Cytotoxicity/viability assays. 

4-Drug metabolizing enzyme assays. 

5-Application of Protein electrophoresis and Quantitaive Western Blotting to study pharmacological actions of plant derived phytochemicals. 

6-Isolation and culture of hepatocytes using collagenase perfusion for phytochemical screening. 

7-Identifying natural inhibitors of the function of efflux proteins (multidrug resistance proteins)

Recent Publication

1-Ali M. El-Halawany;Hossam M. Abdallah;Ahmed R. Hamed;Hany Ezzat Khalil and Ameen M. Almohammadi (2018). Phenolics from Barleria cristata var. Alba as carcinogenesis blockers against menadione Cytotoxicity through induction and protection of quinone reductase. BMC Complementary and Alternative Medicine18:163-online

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-018-2214-9

2-Wagdy M. Eldehna ; Dina H. EL-Naggar; Ahmed R. Hamed; Hany S. Ibrahim; Hazem A. Ghabbourf and Hatem A. Abdel-Aziz (2018). One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells. Journal of enzyme inhibition and medicinal chemistry, 33(1), 309-318.

3- Mervat Morsy EL-Gendy; Shaymaa M .M. Yahya; Ahmed R. Hamed; Maha M. Soltan; Ahmed M. A. El-Bondkly (2018). Phylogenetic Analysis and Biological Evaluation of Marine Endophytic Fungi Derived from Red Sea Sponge Hyrtios Erectus.  Appl Biochem Biotechnol  https://doi.org/10.1007/s12010-017-2679-x.

4-Hamed, A.R.; Emara, M.;Soltan, M.M.; Yahya, S.M.M.; Nabih, H.K.;Elsayed, G.H. (2018). Investigating the role of miRNA-98 and miRNA-214 in chemoresistance of HepG2/Dox cells: studying their effects on predicted ABC transporters targets. Med Chem 27(2), 531–537.

5-Salem, S. M.; Hamed, A. R. & Mosaad, R. M. (2017). Mtdh And Map3k1 Are Direct Targets Of Apoptosis-Regulating Mirnas In Colorectal Carcinoma. Biomed Pharmacother, 94, 767-773.

6-Hegazy, M.-E. F.; El-Beih, A. A.; Hamed, A. R.; Abd El Aty; A. A.; Mohamed, N. S. & Paré, P. W. (2017). 3-Oxo-γ-Costic Acid Fungal-Transformation Generates Eudesmane Sesquiterpenes With In Vitro Tumor-Inhibitory Activity. Bioorganic & Medicinal Chemistry Letters, 27(16):3825-3828.

7- Hegazy, M. F.; Elshamy, A. I.; Mohamed, T. A.; Hamed, A. R.; Ibrahim, M. A. A.; Ohta, S. & Pare, P. W. (2017). Cembrene Diterpenoids With Ether Linkages From Sarcophyton Ehrenbergi: An Anti-Proliferation And Molecular-Docking Assessment. Marine Drugs, Jun 21;15(6). Pii: E192. Doi: 10.3390/Md150601921

8-Yahya, S. M. M.; Fathy, S. A.; El-Khayat Z. A.; El-Toukhy, S. E.; Hamed, A. R.; Hegazy, M. G. A. & Nabih, H. K. (2017). Possible Role Of Microrna-122 In Modulating Multidrug Resistance Of Hepatocellular Carcinoma. Ind J Clin Biochem. doi:10.1007/s12291-017-0651-8.

9- Hussein, S. R.; Marzouk, M. M.; Soltan, M. M.; Ahmed, E. K.; Said, M. M. & Hamed, A. R. (2017). Phenolic Constituents of Pulicaria Undulata (L.) C.A. Mey. Sub Sp. Undulata (Asteraceae): Antioxidant Protective Effects And Chemosystematic Significances. Journal of Food and Drug Analysis, 25: 333-339.

10-Hegazy, M.-E.F.; Hamed, A.R.; El-Kashoury, E.-S.A.; Shaheen, A.M.; Tawfik, W.A.; Paré, P.W.; Abdel-Sattar, E (2017). Stachaegyptin A-C: Neo-clerodane diterpenes from Stachys aegyptiaca Phytochemistry Letters, 21, 151-156

11-Mohamed, A. E. H. H.; Mohamed, N. S.; Hamed, A. R. & Hegazy, M. E. F. (2016). Anti-Inflammatory Activity Of Highly Oxygenated Terpenoids From Achillea Biebersteinii Afan. Zeitschrift Fur Naturforschung - Section C Journal Of Biosciences, 71, 429-432.

12-Ahmed R Hamed*; Mohamed-Elamir F Hegazy; Maureen Higgins; Tarik A Mohamed; Nahla S Abdel-Azim, Paul W Pare; Albena T Dinkova-Kostova (2016) Potency of extracts from selected Egyptian plants as inducers of the NRF2-dependent chemopreventive enzyme NQO1. J Nat Med, 70: 683-8.

13-Ahmed R. Hamed*; Tarik A. Mohamed; Wafaa A. Tawfik; Emad M. Hassan; Maureen Higgins; Sayed A. El-Toumy and Albena T. Dinkova-Kostova (2016) Bioactive polymethoxylated flavonoids from Chiliadenus montanus J chemical and pharmaceutical Research Volume 8 (3):788-793.

14-Walaa A. El-Kashak; Ahmed R. Hamed*; Mohamed El-Raey; Abdelsamed I. Elshamy and Gamal Eldein F. Abd-Ellatef (2016) Antiproliferative, Antioxidant and Antimicrobial activities of Phenolic compounds from Acrocarpus fraxinifolius. J chemical and pharmaceutical Research Volume 8 (3): 520-528.

15-Ali SK; Hamed AR*; Soltan MM; El-Halawany AM; Hegazy UM and Hussein AA  (2016). Kinetics and molecular docking of vasicine from Adhatoda vasica: An acetylcholinesterase inhibitor for Alzheimer's disease. South African Journal of Botany,140, 118–124.

16-Yahya SM*; Hamed AR; Emara M; Soltan MM; Abd-Ellatef GE and Abdelnasser SM (2016). Differential effects of c-myc and ABCB1 silencing on reversing drug resistance in HepG2/Dox cells.  Tumor Biology, 37(5):5925-32.

17- Mohamed-Elamir F. Hegazy; Ahmed R. Hamed;Tarik A. Mohamed; Abdessamad Debbab; Seikou Nakamura; Hisashi Matsudac and Paul W. Paré (2015).’’Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum’’.  RSC Adv. (5): 44895-44901.

18-Maha Mohamed Soltan*; Ahmed R. Hamed; Mona H Hetta and Ahmed A Hussein (2015) Egyptian Pancratium maritimum L. flowers as a source of anti-Alzheimer’s agents. Bulletin of Faculty of Pharmacy, Cairo University 53: 19–22.

19-Khairy A M El-Bayouki*; Wahid M Basyouni; Tamer K Khatab; Fakhry A El- Basyoni; Ahmed R Hamed; Eslam A Mostafa (2014). ‘’Efficient and Expeditious Synthesis of Pyrano-pyrimidines, Multi-substituted γ-Pyrans, and Their Antioxidant Activity’’. Journal of Heterocyclic Chemistry, 51:106-115.

20-Ali SK; Hamed AR; Soltan MM.; Hegazy UM; Elgorashi EE; El-Garf IA and Hussein AA* (2013). In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of Alzheimer disease, BMC Complementary and Alternative Medicine 13: 121(1-10).

21-Abdelshafeek KA; Abdelmohsen MM*; Hamed A and Shahat AA  (2013). Investigation of some chemical constituents and antioxidant activity extracts of matthiola longipetala subsp. Longipetala. Chemistry of Natural Compounds, Vol. 49(3): 539-543.

22-Wafaa H. El-Metnawy*; Mervat M Mattar; Yasser H El-Nahass; Mohamed A Samra; Hala M Abdelhamid; Raafat M AbdlFattah, Ahmad R Hamed (2013). Predictive Value of Pretreatment BCR-ABLIS Transcript level on Response to Imatinib Therapy in Egyptian Patients with Chronic Phase Chronic Myeloid Leukemia (CPCML). International Journal of Biomedical Science, 9(1), 48-53.

23-Ahmed Hamed; Maha Soltan; Jeffrey Fry; Faiza Hammouda; Adel Zaki (2012). Antioxidant and Cytoprotective Properties of Three Egyptian Cyperus Species Using Cell-free and Cell-based Assays. Pharmaceutical Crops, 3, 88-93.

24-Fatma A Bassyouni*; Hanaa A. Tawfik; Ahmed R. Hamed; Maha M. Soltan; Mahmoud ElHefnawi; Ahmed A ElRashedy; Maysa E Moharam and Mohamed Abdel Rehim (2012) Synthesis, antioxidant, and antimicrobial activities of new 2-(1,5,6-trimethyl-1H-benzo[d]imidazole-2-carbonyl)-2,3-dihydro-1H-pyrazole-4-carbonitriles,(1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazol-5-yl)(phenyl)methanones and (1,3,4-oxadiazol- 2-yl)-1,5-dihydro-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitriles: QSAR and molecular docking analysis. EPJ (11): 80-92.

Conferences

<!--MM Soltan, AR Hamed, SS El-Souda, RS Mohammed, AA Matloub (2014). In vitro cytoprotective potential of ornamental Harpullia pendula  highlighting its medicinal value. 62nd Annual Congress of the Society-for-Medicinal-Plant-Research,Guimaraes, Portugal.

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<!--Hamed, A; Wilkinson, A; Kok, W and Fry, J (2007). Induction of quinone reductase and heat shock protein 70 by some phytochemicals. Toxicology 240 (3), 171.

<!--Hamed, A, Shah T, et al.  (2007).  Antioxidant  properties  of  some  extracts  from Adonsonia   digitata L.   using   two   different   automated   cell-free   assays.   Poster presentation   at   the   55th   Annual   Congress   of   the   Society-for-Medicinal-Plant Research, Graz, AUSTRIA, Georg Thieme Verlag Kg.

<!--Hamed, A.,  M.  M.  Soltan,  et  al.  (2007).  In  vitro  screening  of  extracts  from  some  Egyptian plants for their radical scavenging and oxidant reducing properties. Poster presentation  at  55th  Annual  Congress  of  the  Society-for-Medicinal-Plant-Research, Graz, AUSTRIA, Georg Thieme Verlag Kg.

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<!--Hamed,  A  and  Fry,  J  (2006).  Induction  of  Cytoprotective  Mechanisms  by  the Chemopreventive  Isothiocyanate  Sulforaphane  in  Rat  and  Murine  Hepatoma  Cell Lines.Planta Medica (72), 1055. 

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