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Two greenhouse experiments were conducted in clayey soil in order to determine the nematicidal properties of humic acid, hydrogen peroxide, thiamine and two amino acids i.e. phenylalanine and L-Glutamic acid at the concentrations of 100, 500, 1000 and 2000 ppm against Meloidogyne incognita and the potential for induction of systemic resistance in sugar-beet. Results revealed that all treatments with tested concentrations were found to have nematicidal activity against nematode infection and improved plant growth parameters of sugar-beet with various degrees. Humic acid as well as thiamine at the concentration of 2000 ppm proved to be the best for enhancing total plant fresh weight with percentage of increase over control amounted to 148.4 and 142.8% respectively. Root galling and number of eggmasses were significantly suppressed with such materials tested. Leaves of sugar-beet were assayed for their biochemical profiles with respect to NPK, total cholorophyll, proteins, and phenols. However, activities of polyphenol oxidase (PPO), peroxide oxidase (PO) were evaluated in roots of sugar-beet infected with M.incognita. The enzymes accumulation was much greater in thiamine than humic acid treated plants compared to control. The present study revealed the potential of such materials to control root-knot nematode, M.incognita and induce systemic resistance in sugar-beet plant.